What it is

The coenzyme behind every mitochondrial energy reaction in the body — and central to virtually all longevity research published in the last decade.

Why it's studied

NAD+ levels decline approximately 50% by age 50, and this decline is implicated across nearly every hallmark of aging. Restoration of cellular NAD+ pools is at the core of modern longevity science.

Key research findings

• ~50% decline in NAD+ levels by age 50 (Massudi et al., human tissue analysis)

• Central cofactor for sirtuin enzymes and DNA repair pathways

• Documented role in mitochondrial function across longevity research